Paroxetine
Mental healthAlso known as Paxil
Paroxetine is an SSRI antidepressant that's also used for anxiety, panic attacks, and other conditions. It raises serotonin, a mood-regulating brain chemical, and takes two to six weeks to reach full effect. The most important thing to know about paroxetine: of all the SSRIs, it's the one most likely to cause uncomfortable withdrawal symptoms if you stop abruptly — dizziness, flu-like feelings, electric-shock sensations. Always taper off slowly with your doctor's help.
How to take it
When
Once a day, usually in the morning. If it makes you drowsy, ask about switching to evening.
Food
With or without food. Taking it with a meal can ease nausea.
Avoid
St. John's wort and other serotonin boosters. Ask before regular NSAIDs like ibuprofen — SSRIs can raise bleeding risk. Tell your doctor if you take tamoxifen or are pregnant or planning to be.
Stopping
Never stop suddenly. Also watch for new or worsening depression or suicidal thoughts, especially under 25 — tell someone and call your doctor right away.
Missed a dose?
Take it as soon as you remember, unless your next dose is coming up soon — in that case skip the missed one. Never take a double dose.
Common side effects
- Nausea in the first weeks, which usually fades
- Drowsiness or feeling foggy
- Dry mouth
- Sweating more than usual
- Sexual side effects — very common with paroxetine, and something your doctor can help with
Call a doctor if
- Swelling of your face, lips, tongue, or throat — this is an emergency, call for help immediately
- Fever with agitation, racing heart, heavy sweating, or muscle twitching — possible serotonin syndrome, get help now
- Thoughts of hurting yourself — tell someone right away and call your doctor or a crisis line immediately
- Unusual bleeding, black stools, or bruising that won't stop — get medical help quickly
- Seizures — call emergency services