Duloxetine
Mental healthAlso known as Cymbalta
Duloxetine is an SNRI — it raises serotonin and norepinephrine, brain chemicals involved in both mood and how your body processes pain. That double action is why doctors prescribe it not just for depression and anxiety, but also for nerve pain, fibromyalgia, and chronic muscle and joint pain. Give it time: mood benefits take two to six weeks, though pain relief sometimes shows up a bit sooner. Nausea in the first week or two is common and usually passes.
How to take it
When
Once or twice a day at the same times. Swallow the capsule whole — don't crush, chew, or open it.
Food
With or without food. Taking it with a meal can help with nausea.
Avoid
Heavy alcohol use — the combination can stress your liver. Also avoid St. John's wort, and ask before regular ibuprofen or naproxen because of bleeding risk.
Stopping
Don't stop suddenly — taper with your doctor. Watch for new or worsening depression or suicidal thoughts, especially under 25 — tell someone and call your doctor right away.
Missed a dose?
Take it as soon as you remember, unless it's nearly time for your next dose — then skip the missed one. Never double up.
Common side effects
- Nausea in the first week or two — it usually fades
- Dry mouth
- Feeling sleepy or tired
- Constipation
- Sweating more than usual
Call a doctor if
- Yellowing skin or eyes, dark urine, or pain in your upper right belly — possible liver trouble, get medical help now
- Swelling of your face, lips, tongue, or throat, or blistering skin — this is an emergency, call for help immediately
- Fever with agitation, racing heart, or muscle twitching — possible serotonin syndrome, get help now
- Thoughts of hurting yourself — tell someone right away and call your doctor or a crisis line immediately
- Unusual bleeding or bruising that won't stop — get medical help quickly