Divalproex

Seizures and epilepsy

Also known as Depakote

Divalproex boosts a calming chemical in the brain, which prevents many types of seizures and also treats bipolar mood episodes and migraines. It works well, but it asks a lot in return: regular blood tests to watch your liver and your drug level. And one thing you must know — it can cause severe birth defects, so if you could become pregnant, talk to your doctor before starting and use reliable birth control.

How to take it

When

At the same times every day. Some forms are once daily, others more often — follow your prescription exactly.

Food

Take it with food if it bothers your stomach. Swallow tablets whole — don't crush or chew them.

Avoid

Alcohol — it adds to drowsiness. Don't drive until you know how this affects you; seizure driving laws also apply.

Pregnancy

Can cause serious birth defects and learning problems in babies. This is one of its strongest warnings — plan any pregnancy with your doctor.

Missed a dose?

Take it as soon as you remember, unless the next dose is close — then skip the missed one. Missed doses can trigger seizures, so ask your doctor ahead of time what to do. Never double up.

Common side effects

Nausea or stomach upset
Drowsiness
Shaky hands (tremor)
Weight gain
Hair thinning

Call a doctor if

Severe stomach pain that spreads to your back, with nausea or vomiting — possible pancreatitis; this is an emergency, get help now
Yellow skin or eyes, dark urine, unusual tiredness, vomiting, or facial swelling — possible liver damage, especially in the first six months; get help now
A seizure that won't stop — call emergency services
Thoughts of harming yourself, or new or worsening depression — get help now
Unusual bruising or bleeding — call your doctor now

Educational only. This summary is drawn from public FDA labeling and MedlinePlus and simplified for readability. Your prescription label and your pharmacist always come first — doses and instructions vary from person to person.