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Bupropion

Mental health

Also known as Wellbutrin, Zyban

Bupropion isn't an SSRI. It works on dopamine and norepinephrine instead of serotonin, which gives it a different personality: it tends to be energizing rather than sedating, usually doesn't cause weight gain or sexual side effects, and under the name Zyban it's prescribed to help people stop smoking. The trade-off is a small seizure risk, which is why the rules around it are stricter.

How to take it

When

In the morning — taken late it can keep you awake. Extended-release versions are once daily.

Food

With or without food. Swallow extended-release tablets whole — never crush, split, or chew them.

Avoid

Heavy drinking — and don't suddenly quit alcohol while on it either; both raise seizure risk. Tell your doctor if you've ever had seizures or an eating disorder, as bupropion may not be right for you.

Good to know

If you're using it to quit smoking, you start it one to two weeks before your quit date.

Missed a dose?

Skip it and take the next dose at the usual time. Never double up — extra doses raise seizure risk more than a missed one hurts.

Common side effects

  • Dry mouth
  • Trouble sleeping, especially if taken late
  • Headache, mild agitation, or reduced appetite
  • Notably less likely to cause sexual side effects or weight gain than SSRIs

Call a doctor if

Educational only. This summary is drawn from public FDA labeling and MedlinePlus and simplified for readability. Your prescription label and your pharmacist always come first — doses and instructions vary from person to person.